Book Review: A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution (2017). Jennifer A. Doudna & Samuel Sternberg.

This is a personal account by one of the principal inventors of the CRISPR gene editing technology of how she created these astonishing tools for manipulating the underlying chemical structures and design of life forms, with reflections on the ethical and political issues, and technological potential of these new tools for humans to engineer and alter not only nature, but our own inheritable traits as human beings.

It covers some of the same territory with respect to genetic engineering and humanity's future as Bill McKibben does in Falter (previously reviewed here), but from a perhaps more optimistic perspective.

Since this book first appeared, there is now a new version or off-shoot of CRISPR technology which provides far more advanced and specifically targeted gene editing (think character-level search and replace) than the first generation CRISPR tools did, a development which will only increase and accelerate the risks and possibilities explored in this book.

The author, Jennifer Doudna, won the Nobel Prize in Chemistry in 2020 for her work. She is now also the subject of a lengthy biography by the noted biographer Walter Isaacson, called The Code Breaker: Jennifer Doudna, Gene Editing and The Future of the Human Race (2021).

A Crack in Creation, though, allows this brilliant chemist and researcher to explain her life and her groundbreaking work in her own way, and to share her own thoughts on the ethics of the technology she has helped to invent, and what it all means for the future of humanity. Recommended.